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Traditionally viewed as enigmatic and elusive, adenomyosis is a fairly common gynecological disease but is under-recognized and under-researched. This review summarizes the latest development on the pathogenesis and pathophysiology of adenomyosis, which have important implications for imaging diagnosis of the disease and for the development of non-hormonal therapeutics.
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Adenomyosis has been traditionally viewed as an enigmatic disease and, as such, defying effective management. Fortunately, research published in the last decade has helped us to unveil some pathogenesis and pathophysiology of the disease. We now know that EMID can increase the risk of adenomyosis, and Schwann cells within the EMI may play an important role. In addition, the pathogenesis of adenomyosis is surely multifactorial, and EMID is just one such cause.
This is the British genius whose incandescent brilliance did not merely crack the Enigma code in piecemeal or intermittent bursts, but comprehensively crushed it on an industrial scale. Such is his stature that his face and name are on British banknotes, buildings, institutes, and monuments. Turing has become a byword for extraordinary intellectual ability. Even the devastating miscarriage of justice that repaid him so poorly for his incredible loyalty is well documented.
This breakthrough was huge. Now, instead of having to manually try eleventy zillion possible cipher alphabets one by one, cryptanalysts could essentially jump to frequent analysis to at least get them started. Even if some letters mapped across incorrectly, enough might still be correct to identify some partially deciphered words, and as the errors in these words were corrected, the rest of the cipher alphabet could gradually be filled in. In other words, patterns in the orthography of language itself allow the cryptanalyst to induce parts, or possibly all of the cipher alphabet, and crack the code.
How, then, did the battle to crack Enigma begin? As war rages across Europe, and then the world, in the next part we begin to meet the civilians, scientists, and spies who all found themselves caught up in one of the most deadly races against time in modern history.
Born in 1925, Jean Annette Briggs grew up in Bury St. Edmunds, Suffolk County, England. One of three girls, she was a talented artist who attended school in Cambridge. In 1943, at 18, she joined the Royal Navy and her family believed she drove a bus during World War II. Briggs actually operated a BOMBE machine, used to decode German military messages, and worked for master codebreaker Alan Turing. The secret ULTRA project cracked Germany's ENIGMA code. Briggs married U.S. Army Air Corps pilot John Watters (1917-2018) after the war. He flew B-17s, and later the U.S. Air Force colonel served in Korea and Vietnam. The couple raised six children in Bellevue, Nebraska. Jean Briggs Watters died September 15, 2018, and was buried with British military honors. She is interred with her husband in Omaha National Cemetery (Section 3, Site 253).